The Department of Defense (DoD) has launched a cohort of prototype projects to demonstrate treatment technologies for per- and polyfluoroalkyl substance (PFAS)-impacted media. PFAS are very stable in the environment, due to their unique chemical structure, and are relatively resistant to natural breakdown processes. Spread across three DoD-identified installations, these efforts will demonstrate new technologies targeting these chemicals through a partnership with the DoD's Environmental Security Technology Certification Program (ESTCP), the Air Force, the Navy, and the Defense Innovation Unit (DIU). Ten companies have been awarded prototype contracts under this effort. The ESTCP and DIU Environmental Remediation & Restoration from PFAS Initiative combines and compares methods that concentrate and destroy PFAS both on and off-site. The selected projects consist of three discrete actions for PFAS-impacted media: water source remediation, soil treatment, and PFAS destruction.