This 2026 update of the EPA interim guidance presents currently available information on the destruction and disposal of PFAS and PFAS-containing materials. This guidance focuses on updates to the current state of science and associated uncertainties for three large-scale capacity technologies that can destroy PFAS or control PFAS release into the environment: thermal treatment, landfills, and underground injection. This guidance document also discusses emerging technologies and provides a framework for evaluating these technologies for PFAS destruction or disposal. This guidance is non-binding and does not have the force and effect of law.