Pursuant to the U.S. Environmental Protection Agency's Significant New Alternatives Policy program, this action proposes to list several substitutes as acceptable, subject to use conditions, for residential and light commercial air conditioning and heat pumps, chillers, household refrigerators and freezers, motor vehicle air conditioning, and fire suppression and explosion protection. This action also proposes to update use conditions for substitutes previously listed for certain air conditioning end-uses and for water coolers. Comments must be received on or before December 26, 2025, unless a public hearing is held. POC is Emily Maruyama, tele: (202) 564-2809; email: maruyama.emily@epa.gov. (Federal Register 10 November 2025 [Proposed Rule] Pages 50766-50811)