Risk-based water reuse management continues to gain traction throughout the U.S. This presentation will introduce the recent EPA report Risk-Based Framework for Developing Microbial Treatment Targets for Water Reuse, which describes the conceptual framework underpinning these approaches and provides a detailed discussion of current scientific assumptions for conducting the associated quantitative microbial risk assessments (QMRA). In addition to enabling calculation of new fit-for-purpose water treatment levels, it includes computed pathogen log reduction targets (LRTs) across a variety of municipal and onsite reuse configurations. Implementation considerations, key sources of uncertainty, and future research needs are also identified with an emphasis on removal crediting processes.