Illicit fentanyl activities create exposure risks to the general public who unknowingly enter contaminated areas, along with law enforcement, first responders, and remediation contractors who encounter contamination during their official duties. Remediation operations will benefit from improved knowledge of on-site approaches for decontamination or disposition of building materials contaminated with fentanyl and its analogs. Any residual liquid waste containing fentanyl after decontamination may require proper handling and/or treatment prior to disposal. Disposal options for fentanyl contaminated solid waste are limited to incineration. This webinar provides an overview of EPA's role in fentanyl responses and discusses decontamination approaches that fill gaps identified during the development of EPA's Fentanyl Fact Sheet for On-Scene Coordinators. Options to treat fentanyl contaminated liquid waste will be discussed, as well as an overview of EPA's role in defining waste disposal options. This webinar is of interest to the EPA response community, as well as other federal, state, Tribal, and local agencies.