HPVIS is a database that provides access to health and environmental effects information obtained through the High Production Volume (HPV) Challenge. This program "challenges" companies to make this data publicly available on chemicals produced or imported into the United States in quantities of 1 million pounds or more per year. HPVIS enables users to search for summary information, test plans, and new data on HPV chemicals as they are received by the Agency. EPA is carefully reviewing HPV chemical data to characterize the hazards and risks associated with HPV chemicals. HPVIS contains HPV Chemical Hazard Characterizations prepared during EPA's ongoing review of the health and environmental effects data contained with each HPV Challenge Program submission. HPVIS also contains Risk-Based Prioritization documents prepared from EPA's examination of HPV Challenge hazard data along with chemical use and exposure information collected from the 2006 Inventory Update Reporting (IUR). These recommendation documents prioritize HPV chemicals for follow-up data collection or management actions based on their potential risks.