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Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic chemicals that present numerous analytical challenges, including their widespread presence in a variety of environmental samples, occurrence of isomers for some compounds, and precursor transformations that may occur during preservation and storage of the samples. EPA's methods for analyzing PFAS in environmental media are in various stages of development and validation.

EPA scientists are developing validated analytical methods for drinking water; groundwater; surface water; wastewater; and solids, including soils, sediments, biota, and biosolids, which may eventually become standard methods or research methods. Visit EPA's status of PFAS research and development webpage to get updates about this and other PFAS research.

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Last Updated: February 27, 2025